BMBF-Forschungsverbund: SLEEP-NEURO-PATH - Beitrag schlafbezogener Biomarker zur Pathophysiologie von ME/CFS

Dr Claudia Schilling outlined the work of the "Contribution of sleep-related biomarkers to the pathophysiology of ME/CFS (SLEEP-NEURO-PATH)" research network. The 3 sub-projects under the SLEEP-NEURO-PATH research network aim to characterise biological mechanisms associated with brain dysfunction in ME/CFS, such as cognitive disorders, fatigue, headaches, sleep disorders and hypersensitivity to sensory stimuli. Dysfunctions of neuronal networks (detected using selected sleep characteristics) will be assessed by multimodal imaging and biochemical examinations of the function of the vascular bed and supplemented by the determination of polygenic genetic risk profiles. This work is intended to make an important contribution to a better understanding of the pathophysiology of ME/CFS and to help characterise biological mechanisms at the system level. In addition, predictors for ME/CFS at the individual level are to be derived, which offer approaches for future personalised therapy.