Differentiating ME/CFS Through Raman Spectroscopic Profiling of Immune Cells

Prof Christian Puta provided a poster presentation on behalf of Prof Philipp Reuken on differentiating ME/CFS through Raman spectroscopic profiling of immune cells. In their study, Raman spectroscopy was applied to investigate the biochemical profile of leukocytes from post-COVID ME/CFS patients and to examine the immune response. Raman spectroscopy was conducted on peripheral blood mononuclear cells (PBMCs), both before and 24 hours after an exercise test. Following exertion, immune cells in all patients showed significant chemical changes. In contrast, PBMCs of healthy controls did not show significant changes following exertion. The findings indicate potential immunological changes in individuals experiencing prolonged post-COVID symptoms and highlight Raman spectroscopy’s promise as a diagnostic tool.